ICD-10-CM extension with ICD-9 diagnosis codes to support integrated access to clinical legacy data.

INTRODUCTION: ICD is currently the most widely used terminology to code diagnosis and procedures. The transition from ICD-9-CM to ICD-10-CM became effective on October 1, 2015 in US and many other countries. Projects that use this codification for research purposes, requires advanced methods to exploit data with both versions of ICD. Although the General Equivalence Mappings (GEMs), provided by the Centers for Medicare and Medicaid Services, might help to overcome these challenges, their direct use as translation mappings is not possible, mostly due to the further specificity of ICD-10-CM concepts. OBJECTIVE: We propose a methodology to generate an extended version of ICD-10-CM with selected ICD-9-CM diagnosis codes. METHODS: The extension was generated using the GEMs relations between concepts of both terminologies and the hierarchical relations of ICD-10-CM. RESULTS: This extended ICD-10-CM, together with modifications to the mapping of ICD-9-CM concepts that were not inserted, allows the generation of an improved translation of legacy data, raising the number of 1-to-1 correspondences by +13.81%. CONCLUSION: The extended ICD-10-CM enables the accurate integration of ICD-9-CM and ICD-10-CM diagnosis data into a single terminology. With such analysis of data possible without having to specify both ICD-9-CM and ICD-10-CM separately for each query.

ICD-10-PCS extension with ICD-9 procedure codes to support integrated access to clinical legacy data.

Since the creation of The International Classification of Diseases (ICD), new versions have been released to keep updated with the current medical knowledge. Migrations of Electronic Health Records (EHR) from ICD-9 to ICD-10-PCS as clinical procedure codification system, has been a significant challenge and involved large resources. In addition, it created new barriers for integrated access to legacy medical procedure data (frequently ICD-9 coded) with current data (frequently ICD-10-PCS coded). This work proposes a solution based on extending ICD-10-PCS with a subgroup of ICD-9-CM concepts to facilitate such integrated access. The General Equivalence Mappings (GEMs) has been used as foundation to set the terminology relations of these inserted concepts in ICD-10-PCS hierarchy, but due to the existence of 1-to-many mappings, advanced rules are required to seamlessly integrate both terminologies. With the generation of rules based on GEMs relationships, 2014 ICD-9 concepts were included within the ICD-10-PCS hierarchy. For the rest of the concepts, a new method is also proposed to increase 1-to-1 mappings. As results, with the suggested approach, the percentage of ICD-9-CM procedure concepts that can be mapped accurately (avoiding mappings to a large number of concepts) rise from 11.56% to 69.01% of ICD-9-Proc, through the extended ICD-10-PCS hierarchy.

Predictions for the [Formula: see text] decay.

We calculate the shape of the [Formula: see text] and [Formula: see text] invariant mass distributions in the [Formula: see text] and [Formula: see text] decays that are dominated by the [Formula: see text] resonance. The weak interaction part is the same for both processes and the hadronization into the different meson-baryon channels in the final state is given by symmetry arguments. The most important feature is the implementation of the meson-baryon final-state interaction using two chiral unitary models from different theoretical groups. Both approaches give a good description of antikaon-nucleon scattering data, the complex energy shift in kaonic hydrogen and the line shapes of [Formula: see text] in photoproduction, based on the two-pole scenario for the [Formula: see text]. We find that this reaction reflects more the higher mass pole and we make predictions of the line shapes and relative strength of the meson-baryon distributions in the final state.

Novel interpretation of the "θ+ (1540) pentaquark" peak.

We use a theoretical model of the γd→K+ K- np reaction adapted to the experiment done at LEPS where a peak was observed and associated with the Θ+ (1540) pentaquark. The study shows that the method used in the experiment to assign momenta to the undetected proton and neutron, together with the chosen cuts, necessarily creates an artificial broad peak in the assumed K+ n invariant mass in the region of the claimed Θ+ (1540), such that the remaining strength seen for the experimental peak is compatible with a fluctuation of 2σ significance.

Prediction of narrow N* and Λ* resonances with hidden charm above 4 GeV.

The interaction between various charmed mesons and charmed baryons is studied within the framework of the coupled-channel unitary approach with the local hidden gauge formalism. Several meson-baryon dynamically generated narrow N* and Λ* resonances with hidden charm are predicted with mass above 4 GeV and width smaller than 100 MeV. The predicted new resonances definitely cannot be accommodated by quark models with three constituent quarks and can be looked for in the forthcoming PANDA/FAIR experiments.

Simultaneous photoproduction of eta and pi0 mesons on the proton.

The analysis of the gammap-->etapi(0)p reaction has been performed using data from the GRAAL experiment. The total and differential cross sections and the beam asymmetry have been obtained from threshold up to 1.5 GeV of beam energy. The two resonances S11(1535) and Delta(1700) are expected to be excited in the intermediate states of this reaction. The results are used to test predictions based on the assumption that both resonances are dynamically generated from the meson-baryon interaction provided by chiral Lagrangians. The term involving the Delta(1700) excitation, followed by the decay into etaDelta(1232), is found to be dominant.

Evidence for the two-pole structure of the lambda(1405) resonance.

The K- p --> pi0pi0sigma0 reaction is studied within a chiral unitary model. The distribution of pi0sigma0 states forming the lambda(1405) shows, in agreement with a recent experiment, a peak at 1420 MeV and a relatively narrow width of gamma = 38 MeV. The mechanism for the reaction is largely dominated by the emission of a pi0 prior to the K- p interaction leading to the lambda(1405). This ensures the coupling of the lambda(1405) to the K- p channel, thus maximizing the contribution of the second state found in chiral unitary theories, which is narrow and of higher energy than the nominal lambda(1405). This is unlike the pi- p --> K0pisigma reaction, which gives more weight to the pole at lower energy and with a larger width. The data of these two experiments, together with the present theoretical analysis, provide firm evidence of the two-pole structure of the lambda(1405).

Spin, parity, and nature of the xi(1620) resonance.

Using a unitary extension of chiral perturbation theory with a lowest-order s-wave SU(3) chiral Lagrangian we study low-energy meson-baryon scattering in the strangeness S=-2 sector. A scattering-matrix pole is found around 1605 MeV which corresponds to an s-wave Xi resonance with J(P)=1/2(-). We identify this resonance with the Xi(1620) state, quoted by the Particle Data Group with I=1/2 but with unknown spin and parity. The addition of the S=-2 state to the recently computed Lambda(1670), Sigma(1620), and N(1535) states completes the octet of J(P)=1/2(-) resonances dynamically generated in this chiral unitary approach.